Acidosis Decreases Response to Vasopressors?

Acidosis Decreases Response to Vasopressors is a guest post by Jerry Altshuler, PharmD, BCPS, BCCCP One question I commonly encounter on rounds is "does acidosis reduce the activity of catecholamines?" While I think that at this point it is relatively clear that acidosis likely reduces LV contractility due to reduced intracellular calcium entry as well as H+ competition for calcium binding sites on myocardial troponin, I think that the notion that catecholamines "don't work as [...]