Diphacinone Toxicity

Diphacinone Toxicity Daniel Hu, PharmD, BCCCP Critical Care and Emergency Medicine Pharmacist Providence St. Peter Hospital Diphacinone (2-diphenylacetyl-1,3-indanedione, CAS Number 82-66-6) is an indandione-type anticoagulant.1,2 It falls into a class of compounds known as long-acting anticoagulant rodenticides, along with brodifacoum, bromadiolone, chlorophacinone, and difenacoum, which inhibit the synthesis of clotting factors II, VII, IX, and X. These compounds were developed to replace warfarin in rodenticides and many available mouse and rat baits today contain these [...]

By |2019-11-25T13:52:05-05:00September 30th, 2019|EM PharmD|0 Comments

Single Dose Aminoglycoside For Urinary Tract Infections

Single dose aminoglycoside for urinary tract infections, a guest post on empharmd.com Looking for a single dose, no compliance issues, inexpensive, safe, and effective option to treat urinary tract infections? An older therapeutic option might be the answer. A recent systematic review by Goodlet et al. looks into the utility of single dose aminoglycoside for urinary tract infections.1   Article A Systematic Review of Single-Dose Aminoglycoside Therapy for Urinary Tract Infection: Is It Time To [...]

By |2019-11-25T13:52:06-05:00June 6th, 2019|EM PharmD|0 Comments

I Have Andexxa Issues, 2: A Formulary Toolkit

I Have Andexxa Issues, 2: A Formulary Toolkit, a guest post by Zahra Nasrazadani, PharmD, BCPS. Dr. Nasrazadani is an Emergency Medicine Clinical Pharmacist at Salina Regional Health Center. A few months ago, Kristina Kipp wrote her inaugural EMCrit article enumerating her (extremely justified) concerns with the data we had available at the time regarding andexanet alfa…or should I say “coagulation factor Xa (recombinant), inactivated-zhzo”(1)? Since then—and in a somewhat perverse order of operations—the drug has been [...]

By |2019-11-25T13:52:06-05:00April 9th, 2019|EM PharmD|0 Comments

Dose Banding for Pediatric Medications

Why is dose banding for pediatric medications important? If you go to any medication aisle of a store, you can find a wide selection of medications for pediatric patients. Everything from analgesics, cough and cold medications, and agents for gastrointestinal relief. Being a new parent myself, in learning the many ins and outs of infanthood, I did notice something that struck me as rather interesting, perhaps because of my background as an emergency medicine pharmacist, [...]

By |2019-11-25T13:52:06-05:00April 4th, 2019|EM PharmD|0 Comments