Rodenticides And Other Large Animal Toxins
Rodenticides And Other Large Animal Toxins Strychnine/Brucine Effects/MOA Glycine receptor antagonist on spinal cord PNS Clinical Manifestations Conscious seizures, until metabolic demands lead to AMS, multiorgan failure (renal, heart, brain, lung) MGMT/Notes Benzos, cooling, hydration, nondepolarizing NMB, urine alkalinization AC binds 1:1 so 1g/kg x 1 Effective management within first 6 hours is essential Rapid onset vs tetanus (which inhibits glycine release, not competitive antagonism) Professor Touery survived strychnine by also ingesting AC Mole/gopher poison [...]