I recently had the opportunity of recording a podcast episode for the Virtual Critical Care Rounds (VCCR) of the Society of Critical Care Medicine (SCCM) with Sean Kane, PharmD, BCPS (@ClinCalc). We discussed the nuances of acetaminophen toxicity and practical application of the Rumack-Matthew nomogram in the clinical setting.
Some suggested references for the episode are below for review and further reading:
Lin M. Paucis Verbis: Acetaminophen Toxicity. Academic Life in Emergency Medicine (ALiEM). Available at: https://www.aliem.com/2011/11/paucis-verbis-acetaminophen-toxicity/
Sarchi A, Carroll S. Acetaminophen Overdose. EM Basic. Available at: http://embasic.org/acetaminophen-overdose/
Hayes BD. Utility of Pre-4-Hour Acetaminophen Level in Acute Overdose. ALiEM. Available at: https://www.aliem.com/2015/08/utility-of-pre-4-hour-acetaminophen-levels-in-overdoses/
Hayes BD. Are Acetaminophen Levels Necessary in All Overdose Patients? ALiEM. Available at: https://www.aliem.com/2013/09/are-acetaminophen-levels-necessary-in-all-overdose-patients/
Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40(1):3-20.
Hodgman MJ, Garrard AR. A review of acetaminophen poisoning. Crit Care Clin 2012; 28(4):499-516.
Dougherty PP, Klein-Schwartz W. Unexpected late rise in plasma acetaminophen concentrations with change in risk stratification in acute acetaminophen overdoses. J Emerg Med 2012; 43(1):58-63.
Kirschner RI, Rozier CM, Smith LM, Jacobitz KL. Nomogram line crossing after acetaminophen combination product overdose. Clin Toxicol 2016; 54(1):40-6.
ACMT Position Statement: Duration of Intravenous Acetylcysteine Therapy Following Acetaminophen Overdose. J Med Toxicol 2017; 13(1):126-127.
Gosselin S, Juurlink DN, Kielstein JT, et al. Extrip Workgroup. Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. Clin Toxicol 2014; 52(8):856-867.