Rapid Oral Loading of Antiepileptic Drugs

Rapid Oral Loading of Antiepileptic Drugs in the Emergency Department Listen to the podcast by clicking on the link below (link on iTunes available here):  EMPOWER Episode 4 Show Notes: Core content from this episode discussed in: DiPiro's Pharmacotherapy, 9th Edition, Chapter 40 Goodman and Gilman's The Pharmacological Basis of Therapeutics, 12th Edition, Chapter 21 Selection portions of Winter's Basic Clinical Pharmacokinetics, 3rd Edition ACEP Clinical Policy (updated in 2014): Huff JS, Melnick ER, Tomaszewski [...]

By |2019-11-24T17:40:09-05:00August 30th, 2014|EM PharmD|2 Comments

Evaluation of the Contraindications of Class Ic Antiarrhythmics

A Line CAST Too Far: An Evaluation of the Contraindications of Class Ic Antiarrhythmics, guest post by Adam Spaulding, PharmD, BCPS (@PharmERAtom) Flecainide and propafenone are the only Class Ic antiarrhythmic drugs (AADs) available in the United States. These agents block the fast sodium channels within cardiomyocytes, thereby decreasing the rate of rise and magnitude of the action potential. This causes a slowing of conduction velocity, without increasing the effective refractory period. While these agents [...]

By |2019-11-24T17:40:09-05:00August 29th, 2014|EM PharmD|0 Comments

Suspension Or Solution for Ruptured TMs

Suspension Or Solution for Ruptured TMs Topical antibiotic therapy for ear infections isn’t something you’re going to see as an earth-shaking presentation at a good conference, or in a heated debate between the Swami and anyone who dare challenge him. It’s not even something that you would think is driven by dogma and anecdote rather than evidence.  Rarely is it even a thought that is questioned upon reviewing an order or writing a prescription. Generally, [...]

By |2019-11-24T17:40:09-05:00August 20th, 2014|EM PharmD|0 Comments

Managing Overcorrection of Hyponatremia with DDAVP

Managing Overcorrection of Hyponatremia with DDAVP So you have a patient who presents to your emergency department after being brought in by EMS with a three-day history of nausea and vomiting. The patient has had what he describes as a “pretty rough weekend” and admits to have consumed large quantities of alcoholic beverages. While you are examining the patient, the patient has two episodes of tonic-clonic seizures, both episodes subsiding with the administration of benzodiazepines. [...]

By |2019-11-24T17:40:09-05:00August 7th, 2014|EM PharmD|0 Comments