Physostigmine is a reversible cholinesterase inhibitor used in the management of antimuscarinic toxicity.  It differs from pharmacologically similar medications, such as neostigmine and pyridostigmine, due to its tertiary amine structure, which facilitates entry into the central nervous system.  By crossing the blood-brain barrier, we can expect it to be effective for reversal of both peripheral… Read More

Listen to the podcast by clicking on the link below (link to iTunes here): Episode 3: Pipeline Antidotes for Target Specific Oral Anticoagulants Show Notes: Core content from this episode discussed in: DiPiro’s Pharmacotherapy, 9th Edition, Chapter 9 Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 12th Edition, Chapter 30 Published articles and references and… Read More

One of the most entertaining emergency physicians I work with has fallen head over heels in love with intravenous (IV) acetaminophen. He jokes that he orders the product at least once per shift just to get a “visit” from me. I trade jabs, asking how many golf trips he’s received from the manufacturers of IV… Read More