Physostigmine: The Drug The Dogma and the Real Story

Physostigmine: The Drug The Dogma and the Real Story, guest post by Rachel Schult, Pharm.D. Physostigmine is a reversible cholinesterase inhibitor used in the management of antimuscarinic toxicity.  It differs from pharmacologically similar medications, such as neostigmine and pyridostigmine, due to its tertiary amine structure, which facilitates entry into the central nervous system.  By crossing the blood-brain barrier, we can expect it to be effective for the reversal of both peripheral and central signs of [...]

By |2019-11-24T17:40:09-05:00July 29th, 2014|EM PharmD|0 Comments

Antidotes for Direct Oral Anticoagulants (DOAC)

Antidotes for Direct Oral Anticoagulants (DOAC) Listen to the podcast by clicking on the link below (link to iTunes here):   Episode 3: Pipeline Antidotes for Target Specific Oral Anticoagulants   Show Notes:   Core content from this episode discussed in Antidotes for Direct Oral Anticoagulants (DOAC) : DiPiro's Pharmacotherapy, 9th Edition, Chapter 9 Goodman and Gilman's The Pharmacological Basis of Therapeutics, 12th Edition, Chapter 30 Published articles and references and ongoing trials related to pipeline [...]

By |2019-11-24T17:40:09-05:00July 23rd, 2014|EM PharmD|0 Comments

IV Acetaminophen for Pain Management

IV Acetaminophen for Pain Management, a guest post by Meghan E. Groth, Pharm.D., BCPS (@EMPharmGirl) One of the most entertaining emergency physicians I work with has fallen head over heels in love with intravenous (IV) acetaminophen. He jokes that he orders the product at least once per shift just to get a “visit” from me. I trade jabs, asking how many golf trips he’s received from the manufacturers of IV acetaminophen (trade name Ofirmev). I [...]

By |2019-11-24T17:40:09-05:00July 9th, 2014|EM PharmD|1 Comment

The New Scheduling of Tramadol

You may be wondering, “So, what’s the big fuss about tramadol that led to this decision by the DEA?” Is the new scheduling of tramadol a step in the right direction? First, let me start off with a little bit about tramadol itself. Tramadol is a synthetic, centrally acting analgesic. It is actually a racemic mixture, where the (+) enantiomer is involved with binding to the mu opioid receptor as well as inhibition of reuptake [...]

By |2019-11-24T17:40:09-05:00July 3rd, 2014|EM PharmD|1 Comment