The Trauma Cupid’s Arrow: Intracardiac Epinephrine

A patient is wheeled into your trauma bay after a nasty head-on collision on a major highway. According to the paramedics, the downtime and length of anoxia in the patient is unknown, and because of this, the patient is intubated. Vital signs are unobtainable, and pulses are lost on the scene. The patient is now in pulseless electrical activity (PEA), and cardiopulmonary resuscitation is initiated. The decision is made to perform an emergent thoracotomy.

The process is underway and it is time for the next epinephrine dose. The trauma surgeon calls out, “Alright, let’s use intracardiac epinephrine.”

Wait…what? Perhaps this movie scene pops into your head as you hear the order:

Very few case reports and small anecdotal studies describe the use of intracardiac epinephrine in the setting of emergent thoracotomy in traumatic cardiac arrest.

Here are some pointers to remember regarding this technique for administration:

  • The dose is the same dose that is used in the guidelines for advanced cardiovascular life support (ACLS): 1 mg.
  • Use whatever epinephrine product you have available, whether it be the 1:10,000 (1 mg/10 mL) or 1:1,000 (1 mg/mL) concentration; both concentrations have been studied and are acceptable for use.
  • In terms of needle size and length:
    • The best bet to use is an 18-gauge or 22-gauge needle; anything smaller than this is generally not recommended due to the potential for vascular injury to the cardiac tissue.
    • A 1.5-inch needle should be sufficient. Interestingly enough, a number of pharmaceutical companies have manufactured epinephrine specifically for intracardiac injection, which is available in a pre-filled syringe with a 3.5-inch needle attached (fancy, but can create “trauma drama” and probably not truly necessary).
  • Cardiac compressions should be discontinued temporarily while intracardiac administration occurs to prevent injury to the person performing chest compressions.
  • The epinephrine should be administered as rapid push and directly injected into the chamber of the left ventricle while cardiac massage is ongoing. This can be achieved by lifting the heart outwards to allow for easier visualization of the left ventricle.
  • Chest compressions can be resumed once the dose has been administered.
  • The dose of intracardiac epinephrine of 1 mg can be repeated every 3 to 5 minutes, as per the ACLS algorithm.

Some complications that patients may experience include ventricular and coronary artery laceration, pneumothorax, and cardiac tamponade. Because of this, an organized method is necessary for this technique in order to ensure appropriate administration.


2 thoughts on “The Trauma Cupid’s Arrow: Intracardiac Epinephrine

  1. Great post Nadia. One thing i also try to convey to my residents after they see their first EDT is that trauma is trauma, or ATLS… Not ACLS. epinephrine 1mg every 3-5 mins is ok to think about but other agents should be higher on your list of things to think about (e. calcium, NaHCO3, PCC's, etc). keep up the strong work!


  2. I appreciate your feedback. Yes, you are absolutely right; ATLS is the algorithm for trauma and of course, other agents should be considered for management of the life-threatening 6Hs and 6Ts. There is so little available in the literature regarding the use of intracardiac drug administration, so my aim in this post was to really describe the appropriate technique. Thank you for taking the time to read my post and for following the blog.


Leave a Reply

Please log in using one of these methods to post your comment: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.