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Prothrombin Complex Concentrate: Is Less More with Fixed Doses?

Four-factor prothrombin complex concentrate (4FPCC) has been available in the United States for the past two years. We first broke news of its approval by the FDA in the branded form of Kcentra on this blog, and now that we have had clinical experience with it in its use for warfarin-associated bleeding (as well as its off-label use for management of target specific oral anticoagulants as we await the highly anticipated pipeline antidotes of these [...]

By |2015-06-08T10:00:00-05:00June 8th, 2015|EM PharmD Blog|0 Comments

It’s 5 O’Clock in the ED Somewhere: An Intoxicating Review of Antidotal Ethanol

Say you have a patient who consumed almost an entire gallon of antifreeze over a span of 24 hours. Even Animal House’s Blutowski would be concerned, given that an adult who inadvertently sips 10-30 mL of antifreeze should be referred to the emergency department for evaluation of potential toxicity [1]. Initial lab results reveal an ethylene glycol (EG) level of 76 mg/dL, arterial pH of 6.9, and a serum bicarbonate level of 7 mmol/L. The [...]

By |2015-06-01T15:02:00-05:00June 1st, 2015|EM PharmD Blog|0 Comments

It's 5 O'Clock in the ED Somewhere: An Intoxicating Review of Antidotal Ethanol

Say you have a patient who consumed almost an entire gallon of antifreeze over a span of 24 hours. Even Animal House’s Blutowski would be concerned, given that an adult who inadvertently sips 10-30 mL of antifreeze should be referred to the emergency department for evaluation of potential toxicity [1]. Initial lab results reveal an ethylene glycol (EG) level of 76 mg/dL, arterial pH of 6.9, and a serum bicarbonate level of 7 mmol/L. The [...]

By |2015-06-01T15:02:00-05:00June 1st, 2015|EM PharmD Blog|0 Comments