Seizure Risk Associated with Tramadol Use

In an earlier post, the nuances associated with the abuse potential of tramadol and its new schedule IV status, a decision made by the Drug and Enforcement Agency, was discussed. The safety of tramadol in terms of its risk for inducing seizures is a topic that is not clearly understood. There is seizure risk associated with tramadol use, particularly in overdoses because of the possible induction of serotonin syndrome and/or the modulation of monoamine reuptake [...]

By |2019-11-24T17:40:09-05:00September 11th, 2014|EM PharmD|0 Comments

Emergent Treatment of Arrhythmias Associated With Wolff-Parkinson-White Syndrome

Emergent Treatment of Arrhythmias Associated With Wolff-Parkinson-White Syndrome Background: Wolff-Parkinson-White (WPW) syndrome is a congenital cardiac abnormality that manifests itself as a conduction irregularity found between the sinoatrial (SA) and atrioventricular (AV) nodes.  In an otherwise healthy heart, electrical conduction begins at the SA node, which is located in the right atrium.  An electrical pulse is then sent downward causing the atrium to contract and subsequently reaching the AV node, which acts as the connecting [...]

By |2019-11-24T17:40:09-05:00September 4th, 2014|EM PharmD|2 Comments

The Living Systematic Review: An Answer to Knowledge Translation?

The Living Systematic Review: An Answer to Knowledge Translation? Note: An edited version of this post has been featured on MedPage Today. As much as it is may be difficult to ignore the fact that traditional systematic reviews and meta-analyses are full of flaws, they have become the bread and butter for not only the purposes of referencing, but also the very basis of why most of us clinicians practice the way we that we do. It [...]

By |2019-11-24T17:40:09-05:00September 2nd, 2014|EM PharmD|0 Comments